This is a low spread, but this still seems like a great spot in which to bet the underdog. Houston has been excellent against the spread this season, as their cover percentage of 66.7 percent ranks fifth-best in the NCAA. They have only been Catholic University Cardinals Jerseysan underdog once during the 2021-22 season, and that came


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March Madness has lived up to its name so far in 2022. There were upsets galore in the first two rounds of the 2022 NCAA Tournament, and ahead of the Sweet 16, college basketball fans and bettors alike are wondering which Cinderellas will continue their runs to the Final Four.

The Sweet 16 has four double-digit seeds in it: Miami (10), Michigan (11), Iowa State (11) and Saint Peters (15). All four teams have pulled off multiple upsets and have combined to knock off title-favorites like Auburn, Kentucky and Tennessee.

Additionally, No. 8 seed UNC has advanced to the Sweet 16 after knocking out the defending champion Baylor Bears in Round 2 of the tournament.

Bettors may have had their confidence shaken if they had the likes of Baylor, Kentucky and other eliminated teams to win the tournament. Still, there are plenty of reasons to be excited about the upcoming S NCAA Crewneck Sweatshirts weet 16 games, as a dive into the odds reveals some favorable matchups and point spreads of which savvy bettors can take advantage.

What are the best bets for the Sweet 16? Sporting News has you covered with some top trends, advice and picks to take a chance on as March Madness heads towards its second weekend.

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March Madness odds for Sweet 16

Below are the opening March Madness odds for the Sweet 16, including point spreads, money lines and over-under totals for every game, via Sports Interaction Sportsbook.

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Game Spread Moneyline Over/Under
Arkansas vs. Gonzaga GON -8.5 ARK +289 154.5
Michigan vs. Villanova NOVA -5 MICH +170 135.5
Texas Tech vs. Duke TTU -1 DUKE +101 136.5
Houston vs. Arizona ARI -2 HOU +111 145
Saint Peters vs. Purdue PUR -12.5 SPC +497 135.5
Providence vs. Kansas KAN -7.5 PRO +258 141.5
UNC vs. UCLA UCLA -2 UNC +107 142.5
Iowa State vs. Miami (FL) MIA -2.5 ISU +119 133

BENDER: Winners and losers from March Madness' wild first weekend

March Madness best bets for Sweet 16

Houston (+2) vs. Arizona

This is a low spread, but this still seems like a great spot in which to bet the underdog. Houston has been excellent against the spread this season, as their cover percentage of 66.7 percent (24-12 ATS) ranks fifth-best in the NCAA. They have only been an underdog once during the 2021-22 season, and that came in a one-point loss against Alabama.

The Cougars have covered the spread in nine of their last 10 games. Those have all come as favorites of at least 3.5 points, so they shouldn't have any issue covering as an underdog, even against a great Arizona team.

Besides, the Wildcats haven't looked impenetrable in the NCAA Tournament so far. No. 9 seed TCU nearly knocked them off in Round 2 while 16-seed Wright State kept it close in Round 1. They are 5-7 ATS in their last 12, so Houston should have a chance to cover even at this margin.

It wouldn't be a surprise to see the Cougars win this game outright either. They ranked No. 3 in the NET ratings and No. 2 in the KenPom, so they were clearly under-seeded entering the tournament. As such, betting the Houston moneyline +109 isn't a bad choice for daring bettors.

UNC (+114) over UCLA

The Houston moneyline may look appealing, but the underdog in the other 2-point s spread game is just a bit more appealing.

UNC should have a great chance to beat UCLA in the Sweet 16 matchup between the two blue blood p FSU vs. Miami Rivalry shirt rograms. Why? The Bruins will simply have a tough time matc Colorado State Rams clothes hing up with the Tar Heels, especially on the boards.

Armando Bacot and UNC are one of the best rebounding teams in the NCAA Tournament and have logged a plus-24 rebound differential in their first two contests. Meanwhile, UCLA has just a plus-2 differential despite playing weaker competition than the Tar Heels, who blew out Marquette and defeated No. 1 seed Baylor.

Obviously, rebounding isn't the only thing that matters, but UNC is 26-6 strai Notre Dame vs. USC Rivalry Shirts ght up this year when they don't lose the rebound battle while they are 0-3 when they do use it. So, unless UCLA can force UNC into enough misses and clean the glass well, it could end up being a longer day for them than expected.

Purdue (-12.5) vs. Saint Peters

I know, I know. You're scared to bet against the Peacock. Furthermore, you probably don't want to. Who doesn't love a good Cinderella story?

Well, so much as we love Saint Peters' story, the plucky underdog is facing an uphill battle in the Sweet 16. The Peacocks are just the third No. 15 seed in history to make it to this point in the tournament, but no Boston University clothes ne have ever made it to the Elite Eight. So, history would tell us that Saint Peters is unlikely to win this one.

That rings true when you look at the matchup, too. Purdue is one of the strongest teams in the NCAA Tournament and they have something that the Peacocks will have trouble d Fort Lewis College Skyhawks Jerseys ealing with: size.

The Boilermakers sport what is arguably the best center rotation in college basketball. Their starter is 7-4 Canadian Zach Edey, who averages 14.5 points, 7.9 rebounds and 1.3 blocks per game in just 19.1 minutes per contest. When he comes out of the game, Trevion Williams, a 6-10 big man who made the All-Big Ten team in 2021, enters.

Both Edey and Williams have played well during March Madness. Edey has averaged a double-double while Williams scored a team-high 22 points in Purdue's win over Texas. Saint Peters simply doesn't have the size to compete with them, as their biggest regular player, Clarence Rupert, is 6-8. Edey could feast as a result, so don't be afraid to back Purdue as double-digit favorites.

MORE: How Saint Peters compares to other 15 seeds to make the Sweet 16

March Madness best parlays for Sweet 16

UNC vs. UCLA OVER 142.5 and Duke vs. Texas Tech OVER 136.5

If you're either a Duke or UNC fan, pairing the two schools together in a parlay may not be your favorite move. That said, there's good reason to believe that both of these contests will have a chance to hit the over.

The UNC vs. UCLA contest features two of the best offenses in the nation squaring off. The Tar Heels average 78.5 points per game, good for 17th best in the country, while the Bruins at 75.7 points per game are tied for 41st in the country. Both teams possess strong starting lineups that are capable of posting big outings at any time.

So far during the NCAA Tournament, UNC is averaging 94 points per game and has been one of the most efficient offenses during the tournament. Meanwhile, UCLA scored 72 points against Saint Mary's after being uncharacteristically cold in their opener against Akron and scoring just 57 points. Provided that neither team goes cold on Friday, the over should hit.

Meanwhile, Duke is one of the highest-scoring teams in college basketball, as they average 80.3 points per game, good for the sixth-most in the country. The Blue Devils have played in just six games with a point total under 140 and the over is 5-1 in those contests.

Some may be scared off by Texas Tech's top-five scoring defense. However, it's worth noting that the Red Raiders has faced a top-15 scoring offense four times during the season and the over is 3-1 in those contests.

Houston (+111) and UNC (+107)

Upset special parlays can really pay off if you're able to hit the right combination of teams. Both Houston and UNC seemingly have a chance to beat their Sweet 16 opponents in NCAA Spirit Jerseys upset fashion, so why not combine them into a parlay if you're already thinking about betting them?

As mentioned, Houston is one of the most under-seeded teams in the 2022 NCAA Tournament, as they had a legitimate ca UNC vs. Duke Rivalry shirt se to be a No. 2 seed. Instead, they ended up on the 5-line but have beaten UAB and trounced Illinois on route to a meeting with Arizona.

The Wildcats are arguably the most talented team in the NCAA Tournament, but they are light on tournament experience. They also have a first-year head coach in Tommy Lloyd. After their close call against TCU, it's easy to see them falling against Houston.

Meanwhile, UNC has a first-year coach in Hubert Davis, but they aren't heaped with the same expectations as Arizona. They weren't expected to beat Baylor, so anything more of this tournament run is gravy. They match up very well with UCLA scor Buffalo State Bengals shirt ing-wise and should outrebound them significantly to position themselves for a win.

You can bet UNC alone, but combining them in Houston creates a +337 parlay. That payout of nearly 3.4-1 is well worth the risk.

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